August 8, 2022

Random Time

All Health All The Time

Best Immune System Supplements – Top 2021 Immunity Boosters

Your body has its own built-in defense against disease, sickness, and ailments – the immune system. Health is impossible to achieve with a weak immune system. Sleep, age, diet, exercise, all contribute to your ability to stay healthy. Supplements are another way to help strengthen the immunity levels you carry with you day to day.

Those of us born with strong systems are lucky. Some people must improve their ability to stay healthy with external measures. Healthy habits help improve your immunity levels, so your body can ward off disease or illness.

Supplements are everywhere, with new ones constantly released to the market with the promise of keeping you healthy. Some of these supplements are proven to help strengthen your immunity, others are simply hype. Certain natural compounds derived from plants, including vitamin C, Zinc, and plant derivatives, help improve your body’s natural defense system.

Go to your local store, or nutrition shop, you are guaranteed to see dozens of supplements claiming to support your immune system or boost it to the point of perfect health. Unfortunately, not all supplements are created equal. Most offer little to no benefit, proving instead to waste your time and your money. This guide is a comprehensive list of the best immune system supplements on the market available in 2021. Countless hours of research were spent to compile this list of immunity boosters, hopefully, it will shed some light on which to use for your specific needs, and which to stay away from.

Listed immune boosters were ranked after carefully considering various pieces of information. Manufacturer specs, web reports, scientific studies, as well as hard work were used to determine the following list of boosters.

Top Immune System Support Boosters

Mushroom Defense

Everybody knows mushrooms are good for you. Some are naturally better than others, containing high-quality extracts or concentrated doses of rare mushrooms. Mushroom Defense is one such supplement, containing trace ingredients to help improve memory, cognitive function, mental and physical fatigue, plus much more. This specific supplement is also said to help with infection, both viral and bacterial. Not only that but aspects of physical and mental fatigue are improved using Mushroom Defense. Plus, it is made up of purely all-natural ingredients, including a hard-to-find mushroom sourced in Brazil, near the city of Sao Paulo.

Mushroom types found in Mushroom Defense include Agaricus Blazei (Sao Paulo, Brazil), Chaga, Turkey Tail, Reishi, Shiitake, Maitake, Cordyceps Sinensis, Lion’s Mane, and more. For those of you who appreciate all-natural ingredients, rather than synthesized ones, or have a general belief in the holistic healing power of fungus, Mushroom Defense may be the supplement for you. The natural immune booster is backed by a 67-day money-back guarantee and can be purchased for just under $60 a bottle.

VitaPost Immune Support


This all-natural supplement for boosting the immune system is primarily made of botanical extracts for healing your body. Your immune system is in constant barrage by free radicals, toxins, and other unwanted substances. The natural herbs, minerals, vitamins, and extracts making up VitaPost help strengthen your immune system while supporting its longevity.

Made up of ancient ingredients, as well as modern ones, VitaPost Immune Support works to directly affect your immune system, as well as help it by eliminating free radicals from your body. Ingredients found in VitaPost include Vitamin C, Vitamin E, Quercetin, Arabinogalactan, Beta-Glucans, Green Tea, and more. Each of the ingredients is proven to help the immune system stay healthy. VitaPost is one of the most affordable options on the list at just under $15.

VitaPost Immune Complex


Another of the supplements from VitaPost is their Immune Complex. Like the previously mentioned supplement by VitaPost, the complex contains all-natural, proven ingredients. The ingredients list is a little different than the aforementioned. Probiotics is one of the staple ingredients – combined with echinacea, elderberry, and some other holistic ingredients. This is more for improving digestion or warding off an oncoming cold from what I can tell.

If you did not know, the digestive tract is the most important part of your immune system. Healthy bacteria that reside in your gut are vital to healthy immune support. VitaPost Immune Complex promises to help your gut bacteria flourish for under $12.

Simple Promise’s Epishield Plus


Another dietary supplement that claims to work fast. Within two hours, this immune booster claims to start taking effect on your health. That is a bold statement, considering that it is about $50 a bottle, it better work as Simple Promise’s Promise for that price. Ingredients in the pricey supplement are like others we see on this list. The difference, they claim, is that the ingredients used are of higher quality. One ingredient found in Epishield Plus, not seen in each of the previously listed supplements is fermented yeast. Epicor Fermented Yeast as it is called comes from Saccharomyces Cerevisiae. The ingredient makes Epishield Plus unique amongst other supplements. The rumor is that fermented yeast found in this supplement helps to boost your immune system better than any other ingredient.

That does not mean yeast is the only ingredient found in the immune booster. Other ingredients include Mushroom Extract, Vitamin D, Vitamin C, and more. Although it is $50 a bottle, it is a hard supplement to purchase from the company website. For the most part, it is often sold out.

Zenith Labs Nano C


The Vitamin C Supplement, created by Dr. Shelton is claimed to be readily bioavailable because of the liquid form. A lot of vitamins and minerals people take, pass through the system before people properly absorb them into their body. Sometimes it is because of malnutrition, or possibly not eating with it. Whatever the reason is for most supplements not absorbing properly, Zenith Labs Nano C is said to avert that problem. Vitamin C is one of the most important substances known to man for supporting a healthy immune system.

Vitamin C helps you recover faster from bacterial and viral infections. Your body absorbs other nutrients better as well because of Vitamin C. Zenith Labs promises to work so well because it is over a thousand times smaller than traditionally found sources of Vitamin C, hence the name nano. You can buy a bottle of Nano C for just under $50.

Advanced Bionutritionals Resistol


A simple, holistic botanical containing immune support supplement, Resistol goes in a different direction than the other normal supplements on this list. Rather than pump you full of regular everyday nutrients, like Vitamin C, Vitamin D, and the like, Resistol uses not commonly found plant extracts and herbs to help you get healthy.

The five-herb-containing supplement is made up of Andrographis, Platycodon, Eleuthero, and more. They call the ingredients in Resistol, Bionutritionals, something not found in any other supplements on this list. If something different is your thing, you can pick up a bottle for around $30.

Organixx 7M


Here we have another supplement for mushroom fans. Organixx contains several different varieties of mushroom-derived extracts, powders, and similar substances. Mushrooms have long been used to boost immunity in the healthy and the ill. Common mushrooms in the supplement include Shiitake, Reishi, and Maitake. Other less commonly found mushroom types in Organixx 7M are Lion’s Mane, Turkey Tail, and Cordyceps.

Mushrooms do more than simply boost the immune system; they also help reduce inflammation in the body. Inflammation is now linked to many different ailments and chronic illnesses. Beta-Glucans give you anti-inflammatory effects, as well as help clear your body of free radicals. The mushrooms in the supplement are also proven to support the immune system. To benefit from Organixx, you must take the supplement daily. It will help with the immune system, digestion, as well as other symptoms. A bottle of Organixx 7M costs $55.

Bioshield MD


Here we have another supplement created by an MD, Dr. Mark Rosenberg designed Bioshield MD while working for Sun Coast Sciences. His principal concern was the bioavailability of the supplement. Secondly, he considered exact dosages when making it as well. Bioshield MD is more than a simple immune booster however, energy, mental, joint, and digestive health will benefit when taking it.

Unlike other supplements on the list, you know you are getting the right amount of each ingredient. There are no fillers or proprietary blends found in other supplements. Some of the ingredients in Bioshield MD include Cherry, Cocoa, and Green Tea Extract. Others include resveratrol, quercetin and more. Along with helping your health in various ways previously mentioned, the supplement will also help remove free radicals from your body. You can pick up a bottle of Bioshield MD for just under $50.

Vitapost Turmeric & Ginger


Vitapost Turmeric & Ginger have long been used as anti-inflammatory agents, as well as for beneficial digestion. This supplement is for generalized health, immunity support includes. With the right amount of BioPerine, your body’s immune system will flourish. As will its ability to remove toxins and free radicals.

The high concentration of Turmeric & Ginger found in the supplement is ideal for healing properties. Included are black pepper, and the aforementioned curcuminoids to help your body process everything efficiently. The simple, yet effective supplement can be purchased for just under $24.

JayLab Pro’s Immuno Defense 4X


Another simple immune booster, scientifically designed to include just enough of each ingredient, JayLab Pro has created a supplement with only four ingredients. Sometimes, less is more, and that is the case with the simple design in this booster. With only four ingredients, properly formulated in the right amount, your body can easily assimilate each ingredient for maximum effectiveness. The four ingredients found in the immune support supplement are Vitamin D3, Bromelain, Quercetin, and EpiCor.

This is one of two ingredients on the list so far to contain fermented, dried yeast, AKA EpiCor. One bottle of the supplement costs just under $45, making Immune Defense 4X one of the more expensive supplements on the list.

Doctor G’s Q-Ion Immune Defense


Bold statements are made by Doctor G’s Q-Ion Immune Defense Supplement. Claiming the booster helps the body defend itself against viruses, and other pathogens are unique on this list. Also claiming it is Dr approved is not seen anywhere else on this list. Whether or not these claims are fact, is yet to be proven as far as we can tell. The claims are made in correspondence to the anti-inflammatory properties the supplement has.

Created by Dr. John Gordon, including commonly found ingredients like zinc, and bromelain, it seems at first glance to be just like many other immune support boosters on the list. Readily bioavailable, Q-Ion is expensive at just under $80 a bottle.

Immunity 911


Immunity 911 contains more ingredients than any other on the list, it is also one of the most expensive. The issue with the supplement is the amount of each ingredient on the list. Ingredients used in PhytAge are in relatively low doses, likely making them ineffective at treating anything or helping with immunity-boosting power.

The ineffectiveness is speculated by many different health nutritionists regarding the low doses of ingredients like Green Tea, Raspberry extracts. There is also no description of manufacturing standards, or ingredient sources, making it hard to trust Phytage. Still, if you would like to try out the immunity supplement, you can buy a bottle for just under $70.

Immunity Formulas Immune Support


Last on the list, we have a holistically approached immune-boosting supplement. Immunity Formulas, therapeutically designed booster claims to fight pathogens of every type. It operates by boosting your body’s defense-building abilities, usage as a sanitizer, and lastly to purify the air you breathe in. To gain maximum effectiveness, it must be taken daily for a period.

Ingredients are herbal in nature, commonly used for hundreds of years. They include substances like Turmeric, Oregano, and Peppermint, each of which has been used to ward off parasites, diseases, and viruses by cultures around the world. One note, peppermint can be hard on the digestive system, so make sure to test it prior to long-term usage. You can pick up a bottle of the multi-use immune booster for just under $65, also making it relatively expensive compared to other supplements on the list.

Immunity Booster Ranking Standards

To compile the list, we took many factors into consideration. First, we looked at the list of ingredients on each, where they were backed by scientific research? If the ingredients listed were proven to improve the immune system, like Zinc, for example, we gave the supplement points. In accordance with good practices and quality control, we also took into consideration where ingredients were sourced. If there was no way to determine the quality or authenticity of the ingredients, we gave the supplement a lower ranking. Lastly, regarding quality- control, we checked on where each product was manufactured, and what standards they were held to.

Products manufactured in FDA-approved facilities, under Dr supervision, were naturally bumped up on the ranking chart. Supplements without approved manufacturing standards, or those not divulging information were lowered.

The effectiveness of ingredients in each product was looked at carefully, as were the dosages used. If the supplements contained were proven by the FDA to support healthy immune function, we placed it higher on the list. Any companies making unproven claims, or essentially selling snake oils were not given the same respect as those that did, lowering them on the list. Many supplements we looked at were removed outright from the list, as some made claims they could even prevent illnesses like Covid.

There is no supporting evidence, any immune system support supplement can or does treat viruses like Covid-19. Many supplements making claims of this nature were made in countries with little to no regulations, so we did not include them on the list. The products on this list were developed and manufactured in facilities under supervision by an FDA-approved medical advisory board. Essentially, that means they are legitimately supported by medical professionals.

Companies who made the supplements on the list, who we supported, and you can tell by how we reviewed them, have a long history of creating supplements that work. We predominantly only ranked companies with a proven track record and no bad reviews from a medical standpoint. Lastly, we ranked the supplements on the list by price and value. If the price was equivalent to usage value, and effectiveness we gave it a spot on the list.

Side Effects of Immunity Boosters

Many ingredients found in these supplements are proven to have health benefits for the immune system. Vegetables, fruits, herbs, minerals, and nutrients can all have positive benefits to your immunity. Taking supplements alone is typically not enough however, a healthy lifestyle and diet are also required for a boosted immune system. Just the same, poor diet and lifestyle will naturally weaken your body’s natural immunity to viruses and pathogens. It is incredibly important you take all of this into consideration when thinking of your overall health. A doctor will be able to provide you with the most honest advice, following a physical to determine your personal health needs.

Now let us touch on ingredients found in immunity boosters. Some are long proven, Vitamin C, D, Amino Acid Containing Proteins, Zinc, Probiotics, Elderberry, Echinacea, and Turmeric each are proven to boost immunity to unwanted agents from affecting your system. You can get most of these ingredients from a healthy diet, including poultry, red meat, fish, and other superfoods like berries and various veggies.

Garlic and ginger are proven to boost the immune system. Vitamin C is found in most citrus fruits Oranges and Grapefruit. Amino acids in the previously mentioned proteins, as well as many different nuts. Other needed immune boosters like Turmeric, and Echinacea are easier to find in supplements and not common in many household fridges or pantries. Basically, to fully support your immune system, you must include a variety of foods into your diet combined with supplements. The key to effectiveness is research, understanding your body, and making sure the foods you eat are high-quality.

Important Information on the Immune System

Your immune system’s primary function is to stop unwanted agents from entering your body. Your immune system is responsible for everything from tears, and sneezing, both the body’s first line of defense against pathogens, to producing antibodies that fight off infections. T-Cells are created by the immune system, they call into play antibodies to help fight infection, or directly attack pathogens on their own.

The best vitamins you can take for immunity-boosting properties are Vitamins C, D, and E. Each of these vitamins are readily available from food, the sun, and supplements. They help your body’s innate ability to ward off disease and infection. Different organs also support the immune system, recognizing pathogens as they enter your body. It is therefore important to keep your internal organs healthy. You can support your immune-oriented organs like the spleen, and thymus by eating healthy foods like berries, and greens.

Other factors that are proven to improve immune functionality include your weight, sleep habits, drug and alcohol use, and activity levels. Toxic substances are guaranteed to lower your immune system, as is heavy drug & alcohol use. Not sleeping weakens your immune system, as does lethargy. These are all factors that promote healthy immune activity. Basically, to stay healthy, eat healthy, sleep well, stay active, and take the right supplements. It all sounds simple but is not easy in the busy world we live in. Hopefully, this guide will help you when it comes to keeping a healthy immune system, and thereby a higher quality of life.

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.